Perhaps the most important step in treating the brain is eliminating/reducing any substances that may be harming it. Dietary intervention (most commonly for peptides acting as opiates, but also for yeast and bacterial problems) can do this. Removing sources of toxic substances will also have this impact. Correcting nutritional deficiencies and healing the gut will help "feed" a starving brain. There are some specific treatments and supplements that can target the brain in spite of the need to approach treatment holistically.